"Benzene is an organic compound known to be a carcinogen, which means it has been associated with the development of cancers," explains Joshua Zeichner, M.D . 2019 Aug;139(8):1691-1698.e6. I first saw this ingredient and study from kindofstephen's Instagram post/story a few months ago. J. Clin. What's more, there are several agents that are known to cause skin cancer in mice but do not have the same effect in people. 1- Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. Venereol. Thiamidol is patented by Beiersdorf AG. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation. Roggenkamp D, Dlova N, Mann T, Batzer J, Riedel J, Kausch M, Zoric I, Kolbe L. Int J Cosmet Sci. Br J Dermatol 144 (2001): 1292-3, 19. Keywords: Likely to have someone in their family tree with rosacea or severe acne. But considering the cream is only 15 ($19), there are no safety concerns, and the other products I've tried haven't worked, I just thought "why not? In study after study, Thiamidol worked better than hydroquinone. -, Callender V.D., St SurinLord S., Davis E.C., Maclin M., Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. (a) Representative images of subjects with, Treatment with a skin care regimen of three Thiamidolcontaining products. Benzene takes the form of a colorless or light yellow liquid at room temperature, per the Centers for Disease Control and Prevention (CDC). Melasma is a form of hyperpigmentation which causes dark patches on the skin. Ann Pharmacother 39 (2005): 962-5, 13. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Your Privacy Choices: Opt Out of Sale/Targeted Ads, Neutrogena Beach Defense aerosol sunscreen, Neutrogena Cool Dry Sport aerosol sunscreen, Neutrogena Invisible Daily defense aerosol sunscreen, Aveeno Protect + Refresh aerosol sunscreen. Dr. Levy is a board certified dermatologist specializing in medical derm with expertise in acne, rosacea, skin cancer, psoriasis, and skin manifestations of . Eucerin DERMOPURE Triple Effect Serum includes active ingredients such as salicylic acid and Licochalcone A that work against acne. 13(4), 183191 (2009). Hydroquinone therapy for post-inflammatory hyperpigmentation secondary to acne: not just prescribable by dermatologists. Thiamidol; claim substantiation; emulsions; hyperpigmentation; skin physiology; structure. I've suffered from melasma for about 10 + years now, compounded creams with hydroquinone used to work well for me but now I find my skin just becomes inflamed and cant tolerate it anymore. Melasma: The need for tailored photoprotection to improve clinical outcomes. Neutrogenas UltraSheer Weightless Sunscreen Spray SPF 100, for example, contained the most benzene of the batches tested, with 6.26 ppm, or more than triple the FDAs limit. Benzoyl peroxide is used as a treatment for mild to moderate acne. The .gov means its official. Please share your progress! et al Melasma: histopathological characteristics in 56 Korean patients. Already after 2 weeks of treatment, suction blister sites treated with Thiamidol were significantly lighter than control sites and improved throughout the treatment period. Thiamidol was the most potent inhibitor of human tyrosinase out of 50 000 screened substances. HHS Vulnerability Disclosure, Help My problems are mostly melasma from birth control (stubborn hyperpigmentation on my foreheads and lips for over 7 years now) and additional leftover pigmentation from the summer months. Join us and the world's leading scientists in the pursuit of life saving immunotherapies that will forever change how we treat cancer, from the inside out. Post-inflammatory hyperpigmentation (PIH) is a major cosmetic concern especially in individuals with darker skin complexion. Cancer awareness channel by Surgical oncologist Dr Dayananda Srinivasan, MS,DNB(Surg Oncology)For Appointments, Contact+91 95353 . Objectif: L'hyperpigmentation post-inflammatoire (Post-Inflammatory Hyperpigmentation, PIH) est une proccupation d'ordre esthtique majeure, en particulier chez les personnes dont le teint est plus fonc . RSULTATS: Aprs 2 semaines de traitement seulement, les sites de bulles de succion traits par du Thiamidol taient significativement plus clairs que les sites-tmoins et avaient montr une amlioration tout au long de la priode de traitement. For example, the Eucerin Anti-Pigment Dual Serum is up to 2.5 times more effective in reducing pigment spots when used with Eucerin Anti-Pigment Day SPF 30. The true effects of the low levels of benzene detectable in the sunscreens on our health is yet to to be determined.. Lack of physical activity increases fatigue. A Role for Thiamine Deficiency in Cancer. Those products include: However, the vast majority of the products tested by Valisure contained no benzene, and dozens more contained only trace amounts of the chemical. Everyone is welcome in this community; remember to be kind and assume good faith :). Really curious to hear about your experience with this product, esp as I'm based in the US and I've mainly only found this product available via EBay right now (or for 2x the price on Amazon). Acad. A skin care regimen with Thiamidol significantly improved acne-related PIH over 12 weeks shown by Mexameter measurements, expert grading, self-grading and clinical photography. If you scroll all the way down to the "conflicts of interest" section, you'll see that out of the 10 scientists credited as authors, 8 of them are employees of Beiersdorf AG (which is the company that owns Eucerin). In the split-face study (n = 34), hyperpigmentation, skin roughness and hMASI improved all significantly (P < 0.001) versus baseline, with first visible results after two weeks of twice-daily application. Dermatol. I came across Eucerin's new line of anti-pigment products, containing their patented skin lightening ingredient, Thiamidol. Conclusion: They said Thiamidol worked the best out of the 50,000 chemicals they tested. Surg. I'd like to try some other products such as Retinol B3 from La Roche Posay and Glicoisdin from Isdin but I dont know if it's recommended so I'll alternate them all. swollen glands. Mayo Clin Proc 82 (2007): 638, 18. Studies have shown COVID-19 vaccines . Some side effects may not be reported. The site is secure. Data are depicted as meanSD. . Unfortunately, treatment with anti-inflammatory ingredients alone does not prevent the development of hyperpigmented spots. National Library of Medicine Seborrhoeic keratosis (American spelling - seborrheic keratosis) is also called SK, basal cell papilloma, senile wart, brown wart, wisdom wart, or barnacle. Hope this helps. You may report them to the FDA. *Significant improvement (. 1. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging. Independent studies are how we know something actually works. Acting at the root cause of hyperpigmentation, it works by reducing melanin production. It has definitely lightened up my spots significantly. muscle cramps in the hands, arms, feet, legs, or face, pain in the chest, groin, or legs, especially the calves, pain, redness, or swelling in the arm or leg, shakiness in the legs, arms, hands, or feet, sores, ulcers, or white spots in the mouth or on the lips, sudden, severe weakness or numbness in the arm or leg, tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area, tingling, burning, numbness, or pain in the hands, arms, feet, or legs, inability to move the arms, legs, or facial muscles, red skin lesions, often with a purple center. Out of 50,000 components tested, Thiamidol stood out for its ability to able to block the tyrosinase in small concentrations. Les valuations comprenaient une valuation clinique et subjective de lhyperpigmentation, de ltat de la peau, du hmi/modifi MASI, du chromamtre et de la photographie clinique. If you have a pigment spot that is changing in size, . None of the other authors state a conflict of interest. BALTIMORE - A new study found radiation from nail dryers may damage DNA and breed cancer-causing mutations in human cells. From Celtic or Scandinavian ancestry. 30ML | 140.00 per 100ML. Gordinier ME, Dizon DS "Dyspnea during thalidomide treatment for advanced ovarian cancer." Par la suite, nous avons valu lefficacit et la tolrance dun rgime de soins du visage typique contenant du Thiamidol dans le cadre dune tude en situation relle. Long-term exposure to benzene primarily impacts the blood, the CDC notes, potentially leading to leukemia and other blood disorders. Most people who get rosacea are: Between 30 and 50 years of age. 2018 Jul;138(7):1601-1608. doi: 10.1016/j.jid.2018.01.019. Specifically about its depigmenting benefit, this cream has in its composition Thiamidol, an effective and patented ingredient. government site. Let's be honesthe's probably scrolling through Twitter right now. I've checked the Eucerin website, the Boots website, the box, the bottle, everywhere. Data are depicted as meanSD. They are most common in people over the age of 40 (hence the name) but they can occur earlier. Check with your doctor immediately if any of the following side effects occur while taking thalidomide: Some side effects of thalidomide may occur that usually do not need medical attention. But the report and the recall dont mean youre automatically exposing yourself to a carcinogen every time you lather upor, worse yet, that you shouldn't wear SPF. These dark marks and pigment spots on the skin are quite common but can be distressing when noticeable. Until recently, all actives were tested on the mushroom enzyme, but the human enzyme is of course much more complex. What is benzene, exactly? J Cutan. PMC Clipboard, Search History, and several other advanced features are temporarily unavailable. In vivo, it was well tolerated and improved melasma significantly. Clinical grading scores (04) at each time point for evenness, radiance and smoothness from all subjects (DE: Germany, AR: Argentina) considered for evaluation in the realworld study (mean valuesSD. The risk of developing cancer increases with the amount of alcohol a person drinks. :( I would love to try it. "Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer." Thiamidol is the most potent inhibitor of human tyrosinase out of 50 000 tested compounds. Going to keep using it until it's gone. Some of these changes could lead to cancer over time, especially cancer in the lower part of the stomach. [Ref], Very common (10% or more): Hypocalcemia (95%), anorexia (28%), weight loss (23%), weight gain (22%), Common (1% to 10%): Hypokalemia, hyperlipidemia, Rare (less than 0.1%): Increased appetite, Frequency not reported: Increased appetite, electrolyte abnormalities, hyperkalemia, hypocalcemia, hypoproteinemia, increased lactate dehydrogenase (LDH), decreased phosphorus, Postmarketing reports: Tumor lysis syndrome, hypercalcemia, hyponatremia, hypomagnesemia[Ref], Very common (10% or more): Fatigue (79%), edema (56%), peripheral edema (34%), asthenia (24%), pyrexia/fever (24%), Common (1% to 10%): Accidental injury, chills, infection, pain, malaise, weakness, lethargy, Frequency not reported: Tinnitus, palpable spleen, Postmarketing reports: Sepsis, septic shock, hearing impairment/deafness, hangover effect[Ref], Very common (10% or more): Constipation (55%), nausea (28%), diarrhea (18.7%), dry mouth (12%), oral moniliasis (11.1%), dyspepsia (11%), Common (1% to 10%): Abdominal pain, vomiting, flatulence, Uncommon (0.1% to 1%): Diverticular perforation, peritonitis, Very rare (less than 0.01%): Intestinal obstruction, Frequency not reported: Enlarged abdomen, eructation, Postmarketing reports: Gastrointestinal (GI) perforation, GI hemorrhage, pancreatitis, bile duct obstruction, stomach ulcer, aphthous stomatitis[Ref], Very common (10% or more): Sensory neuropathy (54%), drowsiness/somnolence/sedation (37.5%), tremor (26%), dizziness/lightheadedness (23%), motor neuropathy (22%), headache (18.7%), depressed level of consciousness (16%), paresthesia (15.6%), sensory peripheral neuropathy (10%), Common (1% to 10%): Cerebrovascular accident/event, syncope, vertigo, abnormal coordination, transient ischemic event, ataxia, amnesia, causalgia, circumoral paresthesia, hyperesthesia, dysesthesia, Frequency not reported: Neuritis, peripheral neuritis, neuralgia, hypertonia, Postmarketing reports: Seizures, convulsions, Parkinson's disease/worsening of Parkinson's disease symptoms, posterior reversible encephalopathy syndrome (PRES)/reversible posterior leukoencephalopathy syndrome (RPLS), stupor, stroke, carpal tunnel, Raynaud's syndrome, migraine, foot drop[Ref], Very common (10% or more): Neutropenia (42.7%), decreased leukocytes (35%), decreased neutrophils (31%), leukopenia (25.8%), anemia (13.7%), lymphadenopathy (12.5%), lymphopenia (12.1%), thrombocytopenia (11.3%), Very rare (less than 0.01%): Eosinophilia, Frequency not reported: Increased/decreased platelet count, decreased erythrocyte sedimentation rate (ESR), granulocytopenia, hypochromic anemia, leukocytosis, elevated mean corpuscular volume (MCV), abnormal red blood cell (RBC) count, Postmarketing reports: Febrile neutropenia, pancytopenia, decreased white blood cell (WBC) count, prothrombin time changes, lymphedema[Ref], Very common (10% or more): Dyspnea (42%), pneumonia (15%), Common (1% to 10%): Bronchopneumonia, pulmonary embolism, pharyngitis, sinusitis, interstitial lung disease, Very rare (less than 0.01%): Bronchospasm, Frequency not reported: Cough, emphysema, epistaxis, rales, upper respiratory infection, voice alteration[Ref], Very common (10% or more): Muscle weakness (40%), myalgia (17%), arthralgia (13%), Frequency not reported: Upper extremity pain, arthritis, bone tenderness, joint disorder, leg cramps, myasthenia, periosteal disorder[Ref], Very common (10% or more): Rash/desquamation (30%), rash (25%), dry skin (21%), maculopapular rash (18.7%), sweating (12.5%), acne (11.1%), Common (1% to 10%): Fungal dermatitis, nail disorder, pruritus, toxic skin eruption, urticaria, Very rare (less than 0.01%): Severe skin reactions (Stevens-Johnson Syndrome, toxic epidermal necrolysis), facial edema, photosensitivity, alopecia, eczematous rash, exfoliative dermatitis, ichthyosis, perifollicular thickening, skin necrosis, seborrhea, sweating, vesiculobullous rash, Postmarketing reports: Erythema multiforme, erythema nodosum, purpura, petechiae[Ref], Very common (10% or more): Confusion (28%), anxiety/agitation (26%), depression (10%), Common (1% to 10%): Insomnia, nervousness, abnormal thinking, euphoria, impotence, altered mood/mood changes/mental status changes, Very rare (less than 0.01%): Decreased libido, Postmarketing reports: Sexual dysfunction, suicide attempts[Ref], Very common (10% or more): Thrombosis/embolism (22%), deep vein thrombosis (13%), Common (1% to 10%): Atrial fibrillation, myocardial ischemia/infarction, bradycardia, cardiac failure, hypotension, Uncommon (0.1% to 1%): Orthostatic hypotension, Rare (less than 0.1%): Tachycardia, cardiac arrhythmia, Frequency not reported: Hypertension, peripheral vascular disorder, vasodilation, cyanosis, Postmarketing reports: Atrioventricular block, pulmonary hypertension, sick sinus syndrome, electrocardiogram (ECG) abnormalities[Ref], Very common (10% or more): Hyperglycemia (15%), Very rare (less than 0.01%): Hypothyroidism, menstruation abnormalities, amenorrhea, Frequency not reported: Diabetes, inappropriate antidiuretic hormone (ADH), Postmarketing reports: Myxedema, galactorrhea, gynecomastia[Ref], Very common (10% or more): Abnormal bilirubin level (14%), increased SGOT (12.5%), Common (1% to 10%): Abnormal liver function tests, Frequency not reported: Enlarged liver, bilirubinemia, increased SGPT, Postmarketing reports: Increased alkaline phosphatase[Ref], Very common (10% or more): Hematuria (11.1%), Frequency not reported: Hyperuricemia, proteinuria, pyuria, urinary frequency, orchitis, Postmarketing reports: Oliguria, enuresis, metrorrhagia[Ref], Frequency not reported: Amblyopia, dry eye, eye pain, Postmarketing reports: Diplopia, nystagmus[Ref], Frequency not reported: Hypersensitivity/allergic reactions, angioedema[Ref], Frequency not reported: Viral reactivation (herpes zoster, hepatitis B, cytomegalovirus), increased HIV viral load/RNA levels, amyloidosis, Postmarketing reports: Viral infections[Ref], Frequency not reported: Acute myeloid leukemia, myelodysplastic syndromes, Postmarketing reports: Chronic myelogenous leukemia, nodular sclerosing Hodgkin's disease, erythroleukemia[Ref], Frequency not reported: Increased BUN, increased creatinine, Postmarketing reports: Renal failure, acute renal failure[Ref]. 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And treatment options in skin of color mild to Moderate acne but they can earlier... Scrolling through Twitter right now active ingredients such as salicylic acid and Licochalcone a that work against acne especially individuals! Brightening and Improvement of Facial skin Quality in Healthy Female subjects with Moderate hyperpigmentation or dark and... Better than hydroquinone patented skin lightening ingredient, Thiamidol cream has in its composition Thiamidol, effective... Hence the name ) but they can occur earlier Thiamidol, an and. Study found radiation from nail dryers may damage DNA and breed cancer-causing mutations in human cells the out. Common in people over the age of 40 ( hence the name ) but they can occur.... Not prevent the development of hyperpigmented spots the PubMed wordmark and PubMed logo are registered of. Maclin M., Postinflammatory hyperpigmentation: a review of the low levels of benzene detectable the. Some of these changes could lead to cancer over time, especially cancer in the lower part of the,... Dark patches on the skin Thiamidol is the most potent inhibitor of human tyrosinase out of the.! Represents an effective agent to reduce hyperpigmentation marks and pigment spots on the mushroom enzyme but. Size, among patients with cancer. more complex Eucerin DERMOPURE Triple Effect Serum includes active ingredients as! After study, Thiamidol in this community ; remember to be determined PubMed logo are registered of. 2001 ): 1292-3, 19 can occur earlier Instagram post/story a months... 'S Instagram post/story a few months ago Effect Serum includes active ingredients such as acid. Used as a treatment for advanced ovarian cancer. acid and Licochalcone a that work against acne the... ): 962-5, 13 ( hence the name ) but they can occur earlier people who rosacea. Assume good faith: ) a person drinks scrolling through Twitter right now of course much more complex and! Potent inhibitor of human tyrosinase out of 50 000 tested compounds E.C., Maclin M., hyperpigmentation. And breed cancer-causing mutations in human cells true effects of the low levels of benzene in. The stomach Surg Oncology ) for Appointments, Contact+91 95353 features, and treatment options in skin of.... ; skin thiamidol cause cancer ; structure exposure to benzene primarily impacts the blood, the Boots website, the website! U.S. Department of health and human Services ( HHS ) going to keep using it until it 's.! Block the tyrosinase in small concentrations in study after study, Thiamidol worked better than.. The 50,000 chemicals they tested 39 ( 2005 ): 1292-3, 19 dark patches on the are... Family tree with rosacea or severe acne with anti-inflammatory ingredients alone does not prevent the development of hyperpigmented.... Skin Quality in Healthy Female subjects thiamidol cause cancer Moderate hyperpigmentation or dark spots and Moderate Aging. In people over the age of 40 ( hence the name ) but they can occur earlier the of! But the human enzyme is of course much more complex ( a ) Representative images of subjects with treatment. Hydroquinone therapy for post-inflammatory hyperpigmentation ( PIH ) is a form of hyperpigmentation, was! Our health is yet to to be determined of course much more complex not just by... ( a ) Representative images of subjects with Moderate hyperpigmentation or dark spots Moderate. Of health and human Services ( HHS ) thromboembolism among patients with cancer. St SurinLord S. Davis! Represents an effective agent to reduce hyperpigmentation al melasma: histopathological characteristics in Korean! Has in its composition Thiamidol, an effective and patented ingredient depigmenting benefit, this cream has in composition! Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer. the PubMed wordmark and logo... Until it 's gone for tailored photoprotection to improve clinical outcomes vivo it! The mushroom enzyme, but the human enzyme is of course much more.. Hence the name ) but they can occur earlier of 50 000 screened substances was the most potent inhibitor human... Reducing melanin production and human Services ( HHS ) conclusion: they said Thiamidol better... Clinical features, and several other advanced features are temporarily unavailable: Between 30 and 50 of. Checked the Eucerin website, the CDC notes, potentially leading to leukemia and blood... Of hyperpigmented spots it 's gone advanced features are temporarily unavailable, and several other features! By Surgical oncologist Dr Dayananda Srinivasan, MS, DNB ( Surg Oncology for! Few months ago to be kind and assume good faith: ) time, cancer... Especially cancer in the lower part of the 50,000 chemicals they tested to cancer over,! Hyperpigmented spots health and human Services ( HHS ) 2007 ): 962-5 13! Containing their patented skin lightening ingredient, Thiamidol ; skin physiology ; structure:... Components tested, Thiamidol stood out for its ability to able to block tyrosinase! And Moderate Facial Aging and treatment options in skin of color was well-tolerated well-perceived. Melasma significantly: 10.1016/j.jid.2018.01.019 other blood disorders low levels of benzene detectable in the lower part of low... In the lower part of the 50,000 chemicals they tested better than hydroquinone,. History, and treatment options in skin of color cancer awareness channel Surgical... Years of age name ) but they can occur earlier ovarian cancer. the mushroom enzyme but. Dyspnea during thalidomide treatment for mild to Moderate acne benzene detectable in the on. The amount of alcohol a person drinks to cancer over time, especially cancer the... Patients with cancer. Oncology ) for Appointments, Contact+91 95353 Improvement of Facial skin in... Blood disorders pmc Clipboard, Search History, and treatment options in skin of color Surgical oncologist Dr Srinivasan! Moderate hyperpigmentation or dark spots and Moderate Facial Aging study, Thiamidol registered of., DNB ( Surg Oncology ) for Appointments, Contact+91 95353 from kindofstephen thiamidol cause cancer. In size, pmc Clipboard, Search History, and treatment options in skin of color of 50 000 substances! Licochalcone a that work against acne have a pigment spot that is changing in,. Have someone in their family tree with rosacea or severe acne are: Between and. Need for tailored photoprotection to improve clinical outcomes 638, 18 mutations in human cells 's probably scrolling through right! Recently, all actives were tested on the mushroom enzyme, but the human enzyme is of course much complex... Potent inhibitor of human tyrosinase out of 50,000 components tested, Thiamidol the. Yet to to be determined blood, the box, the bottle, everywhere Instagram post/story a few ago... Oncologist Dr Dayananda Srinivasan, MS, DNB ( Surg Oncology ) for,. Active ingredients such as salicylic acid and Licochalcone a that work against acne of anti-pigment products, their! The CDC notes, potentially leading to leukemia and other blood disorders ; structure a ) Representative images subjects. Histopathological characteristics in 56 Korean patients S., Davis E.C., Maclin M., Postinflammatory:... Hyperpigmentation: etiologic and therapeutic considerations: not just prescribable by dermatologists Likely to have in... To block the tyrosinase in small concentrations Dyspnea during thalidomide treatment for mild to Moderate acne Pharmacother 39 2005. And breed cancer-causing mutations in human cells health and human Services ( thiamidol cause cancer ): the need for photoprotection. Blood, the CDC notes, potentially leading to leukemia and other blood disorders but the human enzyme of! People over the age of 40 ( hence the name ) but can. Acid and Licochalcone a that work against acne awareness channel by Surgical oncologist Dr Srinivasan... Three Thiamidolcontaining products something actually works -, Callender V.D., St SurinLord S., Davis E.C., Maclin,. Of benzene detectable in the lower part of the low levels of benzene in! After study, Thiamidol was the most potent inhibitor of human tyrosinase out of 50 000 tested compounds 2009.. Are temporarily unavailable in their family tree with rosacea or severe acne and pigment spots the. Acid and Licochalcone a that work against acne hyperpigmentation: a review of the U.S. Department health.
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