At equivalent doses of 50 mg/kg of body weight, RCZ and ITZ were equally effective and RCZ was more effective than FCZ (P = 0.02). [2], "Hampshire Papers Series 2, Hampshire Field Club & Archaeological Society", "Dr Joseph Stevens (18181899?) Contact Information Get David Stevens Contact Info. Recovery of cfu from the brains and kidneys of survivors showed that no regimen was curative. Beta-1,6-glucan declined 73%. The resistance seen in mouse strain CD-1 is of particular interest in that CD-1 is known to be resistant to endocrine disruption by estrogen. Although no well-designed studies have been carried out, the available data support the use of corticosteroids for acute exacerbations of ABPA (AII). Surgical candidates would need to have adequate pulmonary function to undergo the operation. View details for DOI 10.1080/13693780701644140, View details for Web of Science ID 000252219400001, We compared the efficacy of treatments in a rabbit model of coccidioidal meningitis (CM).Rabbits were infected intracisternally with Coccidioides immitis and treated with intravenous amphotericin B lipid complex (ABLC), deoxycholate amphotericin B (dAMB), oral fluconazole or diluent [sterile 5% dextrose in water (D5W)]. 2nd year: Hydrodynamics. A., Wu, T. D., Shankar, J., Lopes, C. R., Stevens, D. A. Halomonas, a Newly Recognized Human Pathogen Causing Infections and Contamination in a Dialysis Center Three New Species. Champer, J., Diaz-Arevalo, D., Champer, M., Hong, T. B., Wong, M., Shannahoff, M., Ito, J. I., Clemons, K. V., Stevens, D. A., Kalkum, M. Influence of 17 beta-Estradiol on Gene Expression of Paracoccidioides during Mycelia-to-Yeast Transition. However, pioneering studies using Aspergillus particulate forms or homogenates, and recently, recombinant proteins, have demonstrated feasibility. David Stevens was born on 22 December 1940 in Tiberias, Palestine. We reviewed data from all published in vitro studies, animal model studies, and clinical reports and recent abstracts on combination and sequential antifungal therapy for IA from 1966-2001. DCA (Doctorate in Creative Arts: Political and Social Justice), Member: Australian Psychological Society (APS), Fellow of the APS College of the Organisational Psychologists, (Ret.) The Tel Dan inscription, or "House of David" inscription, was discovered in 1993 at the site of Tel Dan in northern Israel in an excavation directed by . More young children have wandered into the pop-up store. View details for DOI 10.1093/jac/dkm264 In a short-term organ clearance study, 5 days of treatment with 10 or 50 mg/kg BID itraconazole or fluconazole reduced the tissue burdens in the brain and spinal cord compared to the tissue burdens in the controls (P < 0.02 to 0.0003). A larger study is indicated for confirmation of this. The objectives of this study were to: (i) see if granulocyte macrophage colony-stimulating factor (GM-CSF) could protect bronchoalveolar macrophages (BAM) against suppression by dexamethasone (DEX) and (ii) test the combined effect of GM-CSF and DEX on lymphocyte responses. When macrophages were pretreated with DEX, GM-CSF could reverse suppression even when added subsequently, provided DEX treatment was discontinued. View details for Web of Science ID 000071515100041. For 24 h after administration of all doses, mean concentrations in serum exceeded MICs for Coccidioides immitis (trough concentrations, greater than 1 microgram/ml). View details for DOI 10.1016/j.vaccine.2009.03.030 CD-1 outbred mice were markedly resistant, with day 6 cfu levels showing a 74- to 87-fold decrease with respect to day 1 levels, whereas other outbred strains (CF-1, SW, ICR) were susceptible. Screening of the isolates by random amplified polymorphic DNA (RAPD) method showed only three profiles. In 1995 I took part in my first major cruise, six weeks in the South Atlantic on theWOCEcruiseA23. Depressed IL-2 production by Con A stimulated CD-1 spleen cells correlated with depressed proliferative responses. She completed a PhD in Egyptian Archaeology at Monash Uni versity in Australia in 2003, with a study of the archaeology of private religion at Amarna . View details for DOI 10.1128/AAC.47.4.1452-1455.2003, View details for Web of Science ID 000181842000049. Cure was not attained with any dosage combinations. Best Match Powered by Whitepages Premium AGE -- David Stevens Little Neck, NY (Northeastern Queens) View Full Report Addresses 68th Ave, Little Neck, NY Phone Numbers (718) Aspergillus species are responsible for most cases of fatal mold infections in immunocompromised patients, particularly in those receiving hematopoietic stem cell transplants. For example, a "no pet allowed" policy could not apply to these animals. Berry, C. D., Stevens, D. A., Hassid, E. I., Pappagianis, D., Happs, E. L., Sahrakar, K. Saccharomyces cerevisiae as a vaccine against coccidioidomycosis. Brummer, E., Antonysamy, M. A., Bythadka, L., Gullikson, G. W., Stevens, D. A. Cooperative enhancement of inhibition by a second drug could eradicate the effect. Most of my research has been involved with cold regions, the Norwegian-Greenland Sea and the Southern Ocean. Hirschi, J., Stevens, D., Brayshaw, D., Czaja, A., Drijfhout, S. & Wadley, M. Research output: Contribution to conference Abstract, Research output: Contribution to journal Article peer-review, Research output: Working paper Preprint. We postulated that DEX inhibition of NF-kappaB was opposed by induction of IkappaB kinases (IKK) by GM-CSF + conidia stimulation, degradation of IkappaB, and release of nuclear factor kappa B (NF-kappaB). These results suggest that metabolism of progesterone to more polar and less inhibitory compounds, which exhibit lower affinity for PBP, is the mechanism of escape from progesterone-mediated inhibition of growth in this organism. Imai, J. K., Singh, G., Clemons, K. V., Stevens, D. A. Paradoxical effect of caspofungin: Reduced activity against Candida albicans at high drug concentrations, Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity. Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. The collection was assembled so that approximately half of the isolates were resistant to azole drugs. Y-related genes, -1,3-glucan synthase, mannosyltransferase and Y20, demonstrated low or delayed expression in E(2)-treated cultures. Infection with T. beigelii should be considered in the differential diagnosis of endocarditis in immunocompetent patients, particularly those who have a prosthetic heart valve. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species.We investigated the efficacy and safety of posaconazole oral suspension (800 mg/day in divided doses) as monotherapy in an open-label, multicenter study in patients with invasive aspergillosis and other mycoses who were refractory to or intolerant of conventional antifungal therapy. > present (Patron of the Association of Science and Discovery Centres) and [????] It was the aim of the present study to assess whether typing of the intergenic spacer region by using restriction fragment length polymorphisms of PCR products (intergenic transcribed spacer PCR [ITS-PCR] ribotyping) could distinguish among type strains of the 10 accepted species of Saccharomyces and further to assess if this method could distinguish strains that were interspecific hybrids. > present (Member of the Advisory Board of the Cheltenham Festival of Science) and [????] Metabolite assays appeared promising but have not been pursued commercially. Concentrations above the MIC of caspofungin allow growth of some Candida isolates. Getty. View Details. Neither concentration in serum, toxicity, nor outcome correlated with dose, calculated in milligrams per kilogram at the fixed doses (400-mg increments) under study. Its also notable that women who are over 30, well educated and relatively affluent are more likely to breastfeed. Here we investigated the possibility that GM-CSF could antagonize DEX down-regulation of interleukin (IL)-1alpha and tumour necrosis factor (TNF)-alpha production by stimulated BAM. Invasive fungal diseases are important causes of morbidity and mortality. We devised a pulmonary infection model in neutropenic BALB/c mice, used an antibacterial regimen to prevent confounding sepsis, and optimized PMN induction, purifications, and dose. Both normal and immunosuppressed animals are used routinely. Fungal burdens in brains and kidneys were reduced after > 0.3 mg of mannan-BSA (all P < 0.05). Catanzaro, A., Cloud, G. A., Stevens, D. A., Levine, B. E., Williams, P. L., Johnson, R. H., Rendon, A., Mirels, L. F., Lutz, J. E., Holloway, M., Galgiani, J. N. Posaconazole therapy for chronic refractory coccidioidomycosis. qPCR appeared to better reflect the progression of untreated infection. View details for DOI 10.1128/AAC.00933-12, View details for Web of Science ID 000308807900041. Saccharomyces cerevisiae is a ubiquitous, ascomycetous yeast, and vaginitis caused by this organism has been reported only very rarely. An aggressive approach to management of this complication has not been the standard of care, but neurosurgical interventional studies combined with physiologic observations suggest early intervention may reduce the devastating morbidity and mortality. BAKER, G., FALK-WHYNES, J. and SIDOROVITCH, A., eds., Teaching for Integrative Learning: Innovations in University Practice. Brains from surviving mice had CFU of Aspergillus fumigatus. [1] All items found, including medieval pottery, were donated to the Reading Museum. Except for the development of flucytosine, there was little progress until the early 1970s and the development of the azole drugs. 2009 Inferring the Function of Projectile Points from the Central Coast of Alta California. View details for DOI 10.1080/13693780500051497, View details for Web of Science ID 000230896300029. Explore how the celebrity world connects. Coccidioidal infections are often difficult to treat, and outcomes can be poor. Cellular DNA, isolated after the lysis of protoplasts, was amplified by PCR using ITS1 and ITS4 primers, purified by liquid chromatography, and digested with restriction endonucleases. MICA given at 1 mg/kg significantly prolonged survival over the saline controls (P = 0.008). Progesterone is also an effective inhibitor of growth of the fungus. British Journal of Politics and International Relations. Of 108 isolates, 97 (95 patient isolates and 2 from the hospital kitchen) were DNA group B and identical in RFLP pattern. Aspergillomas are fungal balls within lung cavities. I am a member of the Centre for Ocean and Atmospheric Sciences. Overall, these data indicate that intravenously administered AmBi is superior to oral FLC or intravenous AMB and that FLC is better than AMB against experimental coccidioidal meningitis. Caspofungin is an important addition to the antifungal pharmacopoeia. CNS aspergillosis is the most frequent and devastating manifestation of dissemination and mortality is high.Cyclophosphamide-suppressed CD-1 mice were infected intracerebrally with conidia of Aspergillus fumigatus and treated for 10 days with suboptimal doses of Abelcet (4 mg/kg) plus micafungin (1 mg/kg), caspofungin (1 mg/kg), itraconazole (100 mg/kg) or voriconazole (40 mg/kg) and compared with monotherapy. Studies were done to develop a murine model that mimics the pattern of mucosal candidiasis followed by disseminated disease seen in patients given cytotoxic chemotherapy. The overlap of normative political philosophy and the philosophy of education. Improvement was noted with amphotericin B or itraconazole followed by voriconazole but not with itraconazole followed by amphotericin B. Political Ideas in Practice: Problem-solving Political Theory. Thanks Alice. > present (Patron of the Natural Sciences Collections Association), [????] After infection with 10(7) CFU, Y55 increased by 13-fold and YJM128 increased by 20-fold in the brain from day 0 to 3. Bronchoalveolar macrophages (BAM) from CD-1 mice killed yeast cells of Blastomyces dermatitidis (Bd) by 25% and this increased to 59% when activated by IFN-gamma. Interleukin 18 (IL-18), transforming growth factor beta1, and IL-12p(40) mRNAs were constitutively expressed in the brains of infected and uninfected mice; IL-2 mRNA was not detected at any time. This paper describes two studies using mallard ducks (Anas platyrhynchos). A high intermittent dose regimen (group A: 10 mg kg(-1) on day 1, 5 mg kg(-1) on days 3 and 6) was compared with standard dosing (group B: 3 mg kg(-1) per day for 14 days) of liposomal amphotericin B (LAB) for empirical treatment of persistent febrile neutropenia. grubii or Cryptococcus neoformans var. This feasibility study suggests that a short intermittent high-dose course of 10/5/5 mg LAB kg(-1) on days 1, 3 and 6 may be as safe and effective as a standard 14 day course of 3 mg kg(-1) per day, with drug-acquisition cost savings and reduced drug exposure. DOES EB VIRUS CAUSE MENINGITIS OR ENCEPHALITIS - RESULTS OF A SURVEY - CASE REPORT, Freeman Spogli Institute for International Studies, Institute for Computational and Mathematical Engineering (ICME), Institute for Human-Centered Artificial Intelligence (HAI), Institute for Stem Cell Biology and Regenerative Medicine, Stanford Institute for Economic Policy Research (SIEPR), Stanford Woods Institute for the Environment, Office of VP for University Human Resources, Office of Vice President for Business Affairs and Chief Financial Officer, Acad Council, Medicine - Infectious Diseases, Maternal & Child Health Research Institute (MCHRI). Proliferation of HKY-stimulated spleen or lymph node cells was tested by Alamar Blue reduction and flow cytometry. Limited analysis of the ERG11 gene sequence identified several point mutations in resistant isolates; these mutations have been described previously. We have previously determined the relative virulence of isolates of Saccharomyces cerevisiae on the basis of differences in proliferation and resistance to clearance in CD-1 mice. We also analysed gene expression with time in culture and found that while transposable elements and components of respiratory pathways tended to increase in expression with time, genes encoding ribosomal structural proteins and protein catabolism tended to sharply decrease in expression over time, particularly in yeast. Galactomannan antigen testing of blood is routine in some European centres, with EIA methodology supplanting agglutination because of apparently greater sensitivity. In addition, YJM128 increased by 4-fold in the kidneys, whereas Y55 decreased by 16-fold. Early diagnosis of fungal infections in cancer patients is problematic. Zeamatin, a natural plant-derived antifungal protein, was tested alone and in combination with an azole, clotrimazole or nikkomycin Z, a chitin synthase inhibitor.Whereas alone, zeamatin was ineffective, nikkomycin Z was effective only when dosed multiple times per day, and clotrimazole efficacy was variable when administered in experimental vehicles (unlike the complex and undefined commercial preparation), zeamatin enhanced the efficacy of either of the other two drugs when they were given in combination.Drug interactions between novel drugs with unique mechanisms of action should be explored further, and may lead to more potent regimens. Lipid formulations of amphotericin are indicated for the patient who has impaired renal function or who develops nephrotoxicity while receiving deoxycholate amphotericin (AII). We have shown heat-killed Saccharomyces (HKY) is a protective vaccine against aspergillosis and coccidioidomycosis. Staff should be educated on the proper terminology and procedures to prevent a blurring of the categories and roles of these animals. Then there was little progress for 50 years, when in 1951, nystatin was introduced, the first useful polyene. Growth occurs by hyphal tip extension, in which the hypha elongates and a septum is formed behind the tip to divide it in to a separate compartment. Your husband stayed at home to look after your daughter Phoebe in 2012. However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. Conversely, GM-CSF decreased I kappaB levels. Plating for A. fumigatus from the brain confirmed that all mice had burdens of log>3 from 4 to 120 h after infection. PhD student in Archaeology Dr Anna Stevens. View details for DOI 10.1128/AAC.49.4.1369-1376.2005, View details for Web of Science ID 000228082500018. Joseph Stevens (born 14 April 1818, died 7 April 1899) was a British archaeologist, former medical doctor, and antiquarian. Shankar, J., Restrepo, A., Clemons, K. V., Stevens, D. A. We investigated BALF enhancement or inhibition of TNF-alpha production by BAM stimulated by B. dermatitidis. Other studies have shown efficacy in cryptococcal meningitis in AIDS comparable to conventional therapy and with far less toxicity, and also in prevention of relapse of cryptococcal disease. This cytokine profile does not suggest a polarized Th1 or Th2 response. [1] He has been heralded by past curator of natural history at Reading Museum, David Norton, for his approach towards curating, citing that he can be perceived as a "pioneer in seeing museums not as cabinets of curiosities but as places of education and particularly of their localities" after discussing how Stevens refused a chipped off stone fragment from Stonehenge out of concern that it would promote further destruction. Four responses were complete and seven were partial; these included five patients with pulmonary sites and six patients with disseminated sites. Factors associated with a poor prognosis have been defined and therapy is difficult because of the lack of a blood supply. This review addresses a variety of uses for animal models in medical mycology. View details for DOI 10.1196/annals.1406.039, View details for Web of Science ID 000250750700039, Cryptococcus neoformans (Cn) var. Ravuconazole has good efficacy and the potential to cure mucosal candidosis in the absence of a functional immune response. and more from FamousFix.com, Dr Alice Roberts, Dr. Alice Roberts, Prof Alice Roberts, Prof. Alice Roberts, Professor Alice Roberts, @ancientmodernist-(facebook), Ancientmodernist - (instagram), @theAliceRoberts - (twitter), Professor Alice Roberts BSc MB BCh PhD Hon.FBAASc, She is known for her long henna-red (dyed) hair., In 2015 her book 'The Incredible unlikeliness of Being' was shortlisted for the Wellcome Trust Book Prize, In 1988 she won the Blue Peter Young Artist competition aged 15, which saw her appear on the Radio Times cover in 1988., Qualifying as a doctor in 1997, she left medicine after only 18 months, having met her future husband, field archaeologist David Stevens, at Cardiff University., She is a Humanist: it is the most rational and positive philosophy for life., She made her television debut in 2001 as a human bone specialist on Channel 4s Time Team., She taught Anatomy to medical students at Bristol University for 11 years., She is, Westbury C-of-E Primary School, Redmaids' High School, [1991 - 1997] - University of Wales College of Medicine [MB BCh (medical degree)], [????] Peritoneal macrophages (PM) from CD-1 mice had significant fungicidal activity for Bd (43%) and this increased to 63% with IFN-gamma treatment. Clemons, K. V., Park, P. S., McCusker, J. H., McCullough, M. J., Davis, R. W., Stevens, D. A. Mannan-BSA (500 kDa) was more protective than 40 kDa mannan-BSA. Nineteen S. cerevisiae isolates obtained from patients suffering from vaginitis and four isolates from commercial products in the same city were analyzed. Ascioglu, S., Rex, J. H., de Pauw, B., BENNETT, J. E., Bille, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., Fiere, D., Lortholary, O., Maertens, J., Meis, J. F., Patterson, T. F., Ritter, J., Selleslag, D., Shah, P. M., Stevens, D. A., Walsh, T. J. Intrathecal amphotericin in the management of coccidioidal meningitis. Three levels of probability are proposed: "proven," "probable," and "possible." Do you find it difficult to juggle motherhood with your media career? Because vasculitis is seen frequently in patients with coccidioidal meningitis (CM), this study evaluated the presence of MMP-9 within the cerebrospinal fluid (CSF) of rabbits infected intracisternally with Coccidioides immitis arthroconidia. GM-CSF reversed the effect of DEX on I kappaB levels. Help keep Alice Roberts and David Stevens profile up to date. TNFalpha production by young macrophages (BAM or PM), when cocultured with Bd for 18 h, was half of TNFalpha secreted by adult macrophages. View details for Web of Science ID 000177999000007. Born in . With aspergillosis, predictive clinical correlates have been defined, respiratory tract cultures are highly predictive of invasive disease in the appropriate setting and certain CT scan findings enable early diagnosis. This property can be considered a virulence trait and may help explain the presence of these isolates in human hosts. Liked by David Stevens. Singh, G., Imai, J., Clemons, K. V., Stevens, D. A. Production of the proinflammatory cytokines interleukin (IL)-1 alpha and tumor necrosis factor (TNF)-alpha and of the chemotactic chemokine macrophage inflammatory protein (MIP)-1 alpha by bronchoalveolar macrophages (BAMs) from mice in response to Aspergillus conidia was tested after in vivo administration of saline, dexamethasone, cortisone acetate, granulocyte-macrophage colony-stimulating factor (GM-CSF), or a combination. Coccidioides, a fungus, is endemic to specific parts of the Western Hemisphere. No overt signs of toxicity were observed during any of the studies regardless of administration route, and no histologic lesions/changes were attributed to VRC treatment. Was King David a real person? Amphotericin B tissue and serum concentrations did not correlate with efficacy. Against isolates that show paradoxical growth in vitro, CAS was efficacious, but lacked dose responsiveness above 0.5 mg/kg against three of the four. It should now be possible, by this simple PCR-based technique, to accurately identify these strains to the species level, thereby allowing an increase in our understanding of the characteristics required by these interspecific hybrids for their particular ecological niches. A model was used to compare the efficacies of itraconazole and fluconazole. Stevens, D. A., Kim, K. K., Johnson, N., Lee, J., Hamilton, J. R. Experimental Evidence That Granulocyte Transfusions Are Efficacious in Treatment of Neutropenic Hosts with Pulmonary Aspergillosis. McCusker, J. H., Clemons, K. V., Stevens, D. A., Davis, R. W. PULMONARY MUCORMYCOSIS PRESENTING AS AN ENDOBRONCHIAL LESION. Gender. A model of orogastric candidosis in SCID mice, which mimics disease seen in AIDS patients, was used to evaluate ravuconazole in comparison with fluconazole for treatment. Significant enhancement of survival over the respective monotherapies was found only with the combination of Abelcet and voriconazole. Birthday: May 19, 1973 ( Taurus) Born In: Bristol 69 14 Anthropologists #12 Intellectuals & Academics #237 Quick Facts British Celebrities Born In May Also Known As: Alice May Roberts Age: 49 Years, 49 Year Old Females Family: Spouse/Ex-: David Stevens (m. 2000) children: Phoebe Stevens Anthropologists British Women I welcome applications throughout the year from potential PhD candidates with an interest in oceanography or climate processes for available positions or from candidates who have their own funding or wish to apply for their own funding. The objective of the present work was the identification of new microsatellite loci able to distinguish among C. parapsilosis isolates. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. The laboratory has used molecular fingerprinting systems applied to the genomes of fungal species to develop tools to allow typing and differentiation of clinical isolates and for epidemiological and taxonomic purposes, particularly the epidemiology of Aspergillus and the Candida parapsilosis family. These data detail the immune response in the brain and could be important for the future design of specific immunomodulatory therapies for this important opportunistic infection. The innovative approach to business planning described in this book is the result of not only many years research, but of the experience of running over 300 participatory sessions in a whole range of enterprises, in every State in Australia as well as other countries throughout the world. The protective moiety(ies) appeared to reside in the cell wall and was resistant to 100 C, but not to protease or formalin. Managing Director, Maunsell Management, Hong Kong. Co-stimulation with granulocyte-macrophage colony stimulating factor abolished immunomodulatory effects of the drugs. A Celebrated West Texas Archaeologist Has Been Firedand No One Will Say Why. Stevens, D. A., Kullberg, B. J., Brummer, E., Casadevall, A., Netea, M. G., Sugar, A. M. Cryptococcal meningitis in the immunocompromised host: intracranial hypertension and other complications. According to our records, Alice Roberts is possibly single. In combination, Abelcet and caspofungin were equivalent to Abelcet alone.Abelcet proved to be efficacious, but not curative, in the treatment of CNS aspergillosis and was equivalent overall to conventional AmB. Its still unusual to find stay-at-home husbands but the reforms to maternity leave due in 2015 should make it easier for families to make this choice, if it suits them. (ODYSEA), Decadal variability of the extratropical response to the Madden-Julian Oscillation, North Atlantic Oscillation response to the MaddenJulian Oscillation in a coupled climate model, Reversal of ocean gyres near ice shelves in the Amundsen Sea caused by the interaction of sea ice and wind, Seasonal extrema of sea surface temperature in CMIP6 models. PCR has been made specific by genus-specific probes, with 100% sensitivity and reasonable specificity. One week after the cessation of therapy, all survivors were euthanatized, the numbers of CFU remaining in the spinal cord and brain were determined, and histological analyses were performed. In contrast, BAM from BALB/c mice lacked significant killing (5%) of Bd but could be activated by IFN-gamma for enhanced killing (19%). View details for DOI 10.1128/AAC.06015-11, View details for Web of Science ID 000306826300050. View details for DOI 10.1097/MAJ.0b013e31825600de. Many fungi have been shown to use hormonal (pheromonal) fungal molecules for intercellular communication, and there are increasing numbers of examples of interactions between mammalian hormones and fungi, including the specific binding of mammalian hormones by fungal proteins, and suggestions of mammalian hormonal modulation of fungal behavior. Alice Roberts is a member of the following lists: 1973 births, 20th-century English people and 21st-century English people. Multiple Modes of Monumentality: Case Studies from the American South. In "The Dawn of Everything," the anthropologist David Graeber and the archaeologist David Wengrow aim to rewrite the story of our shared past and future. Mouse serum and heat-inactivated mouse serum inhibited TNF-alpha production 94% when macrophages were stimulated by B. dermatitidis, whereas mouse immunoglobulin G (IgG) did not have this effect. View details for DOI 10.1371/journal.pone.0059237, View details for Web of Science ID 000316549400044. 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