EDIT: NL now has Dead God, items are no longer bolded. A new study out of Sweden has found that those who contract COVID-19 have an increased risk of certain types of blood clots, which can be fatal, up to six months after infection. Haemolacria is an unlockable passive item added in The Binding of Isaac: Afterbirth (Booster Pack #4). Attempting to fire the beam before it is fully charged will cancel the charge. This effect can't be abused - next time it will be empty if dropped, UNLOCK: Unlock this trinket by defeating Mother as Tainted Magdalene, Every 15 shots you will shoot an Ipecac + My Reflection shot, The tear will fly in the air for about 3 seconds and follows Isaac until it falls and explodes. A dead sea in a dead land, grey and old. "Charged burst attack" at base damage of 3.5, that's 45 damage), Self-inflicted damage such as Blood Donation machines don't trigger this effect, Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide), Item Pool: Item Room, Greed Mode Item Room, Bomb Beggar. Explosion damage has increased to 100 (from 60). effect for the floor, UNLOCK: Unlock this item by beating Satan with Eden, Item Pool: Item Room, Library, Secret Room, * library pool, library room, book room pool, secret room pool, item room, treasure room, Trinkets Brimstone ticks 9 times in about 1 second. It isn't 100% effective but the effect is very strong and will deflect most shots under a bullet hell situation. [Check ingame], PS4 J21Z FJ0W (Second Floor Devil Room), Switch DBDR SJGV (First floor Devil Room), 3DS EXDL 3P62 (First floor Devil Room), PC WVV7 FTPE (Second Floor Devil Room), PC W48H DB1O ( Tammy's Head in First Floor Treasure Room, Third Floor Devil Room), PC 63YH C0AE (Second Floor Devil Room), Achievements 5.100.229 poop, When used, you have a 50% chance to double all items, consumables and chests in the current room, If the effect fails, all pickups and items are deleted and Crooked Penny spawns 1 coin, If there are no consumables currently on the floor, Crooked Penny spawns 1 coin, This item works with items which can be purchased such as shop items, allowing you to spawn a free version if the effect triggers, If used in a shop and the effect fails, a Restock box can be used to restore the shop items. However, If you also have flying you will always take damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, bomb, A random chance when you take damage to get an invincibility shield for 7 seconds, The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit, Converts all negative pills into their positive counterparts e.g. The door can only be opened if you have The Polaroid, The Negative or Faded Polaroid (the item/trinket is taken away when it opens). They also no longer block player attacks or get extinguished by them, UNLOCK: Unlock this item by donating 400 pennies to the Shop, Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar, Soul hearts and black hearts cannot be stored, If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart, * shop room pool, shop item pool, the lost item pool, glass. (2) $19.99. However after the attack you end up near the boss, which puts you in danger of taking damage too, Scales in damage and area of effect with the player's size, UNLOCK: Unlock this item by defeating Delirium as Jacob & Esau, When used will do a swipe attack in any direction. Speed Up will be +0.3 instead of +0.15. Rooms Blood Clot is a passive item. Effect. After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. Frogsplat Apr 2, 2014 @ 5:11pm. One of the following messages may show: "Some doors require a blessing. The next room you enter he will automatically fire a massive red brimstone laser for 4 seconds, dealing huge damage, The rage resets back to zero, and the cycle continues every 5 rooms cleared, UNLOCK: Unlock this item by defeating The Beast as Tainted Azazel, When using a card, pill, or rune, you also use a copy of the last 3 cards/pills/runes you used after picking up Echo Chamber, UNLOCK: Unlock this item by defeating The Beast as Tainted Apollyon, Spawns an Old chest at the start of all future floors, Old Chests work the same as Golden Chests, requiring a key to open but contain different items, The Old chest can contain: 3 trinkets (42% chance), 1-3 soul hearts (43% chance), a random item from the Old Chest pool (10% chance) or an angel room item (5% chance), Spawns a second chest in the mirrored floor of Downpour II or Dross II, but only if you had this item before entering the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Forgotten, Each time you take damage, a red flame orbital will appear around Isaac for the remainder of the floor, up to a maximum of 6, The flames deal contact damage which scales with your tear damage, Upon reaching 6 flames, they will also start to fire tears along with Isaac, dealing a flat 3.2 damage per tear, When entering a new floor, all the flames disappear, UNLOCK: Unlock this item by defeating The Beast as Tainted Bethany, Using this item swaps you between the character you started as, and Esau, which has 3 black hearts, +2 base damage and the ability to fly, This character keeps its own separate health and items. Bad Trip becomes Balls of Steel. Monsters Transformations Here's how to unlock each tainted character and what makes . Type: Passive, Familiar . Picking up Brimstone will multiply Isaac's current damage by 3. when entering the item room, Gives +1 Soul Heart when starting each new floor after picking this up, Currently this effect doesn't work in Greed Mode - It will show 2 items but the item rooms will have different items in them, Gives +0.4 Tears Up for each room completed without taking damage, up to a maximum of +2.0 Tears Up, When you take damage, the tears bonus is reset, Picking this item up counts and gives you a temporary +0.4 Tears Up as well, Allows you to double-tap the shoot button to create a holy shield for 1 second that pushes enemies back and deals 10 damage to them if they touch it, The shield also reflects enemy shots and beams back at them for some extra damage, Can only be activated every 3 seconds (Shown by a white glow and a ticking noise). Blood Clot: All tears are larger, with increased damage (as opposed to every 2nd tear like Blood Clot alone). Stealing an item has a chance to fail (a buzzer sound will play if it fails), Enemies: Attacks the enemy until either the ghost or the enemy dies, Doors: Opens the door, even if it is locked, Secret room entrances: Explodes and opens the entrance, Boss rush door: Will open the Boss Rush door from either side, allowing you get into and escape the Boss Rush, Slot machines, dead shopkeepers: Charges towards them and explodes them, Added as part of the Afterbirth+ Booster Pack #3. First, chemical signals cause the injured vessels to narrow to prevent more blood from leaking out. Cannot be rerolled by 4-pip dice rooms and Spindown Dice, Clearing a room will spawn an extra reward, however only one can be picked up - the other one will disappear, UNLOCK: Unlock this item by defeating the The Beast as Isaac, Every half red heart you pick up gives a small but permanent stat increase, Randomly picks between +0.10 Damage Up, +0.05 Tears Up, +0.15 Range Up, +0.02 Speed Up, +0.1 Luck Up, +0.02 Shot Speed Up per half red heart, UNLOCK: Unlock this item by defeating The Beast as Magdalene, This item causes Devil deals to cost money instead of hearts, and shop items to cost hearts instead of money, Shop items cost heart containers, and pickups have spikes around them, The Devil deal conversion rate is 1 heart container to 15 coins, Devil deal items can be on discount similar to the shop, making it 1 heart container = 7 coins instead, UNLOCK: Unlock this item by defeating The Beast as Cain, Every time you enter a devil room and choose not to take an item, you get +1 Damage Up upon entering the next floor, The effect is shown via a cross above Isaac's head. Rooms Tears are now white, do a lot more damage and move slower across the screen with a homing effect, * angel room pool, god room pool, angel room item, red, fire, flame, orange, cross, Does not increase your damage, simply makes your tears red, * boss room pool, boss room item, sticks, brown, yellow, * angel room pool, god room pool, angel room item, the lost item pool, cup, wooden, gold, in an Angel room, this will spawn 2 Angel room items), Starts with 0 charge and requires 12 charges to use, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Eden, Every 6-7 rooms Acid Baby will drop a random pill, Every time you use a pill, Acid Baby will deal 10 damage to all enemies and poison them for 6-7 ticks, REPENTANCE - Poison effect is stronger, but Acid Baby's pill drop rate has been reduced to every 6-7 rooms (previously every 2-3 rooms), A familiar fairy that will float around the room and highlight the location of any secret room doors, tinted rocks or trapdoors under rocks, Upon entering a new room, if there is an undiscovered secret room or tinted rock, it will move directly to the point of interest, otherwise it will just randomly fly around the room, For every empty red heart container, Isaac gains Damage Up and his body increases in size, Only works on full hearts - damage does not change if Isaac is missing 1/2 of a heart in one container, Healing empty red heart containers will remove the damage increases, Has no effect for The Lost and ?? Devil Rooms / I AM ERROR rooms, UNLOCK: Unlock this item by defeating Mother as Apollyon, You gain a familiar that lives under the floor. grey, gray, green, mouth, bobs rotten head, bob rotten head, Teleports Isaac to a random location on the map, Can't be used to teleport to the I AM ERROR room, REPENTANCE - Teleport! in shops or devil rooms), The only way to survive the falling sword is either through extra lives, by using items that would make you invincible, such as Gnawed Leaf or playing as The Lost. Starts at +3.6 damage and goes to 0 after 30 seconds, While this temporary damage boost is active, each enemy you kill increases your damage slightly, allowing you to quickly kill multiple enemies and chain the effect for longer, This item also gives a -0.03 Speed Down for every food item held. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, #7. See its page for a full list, with only differences listed here. It can spawn familiars you haven't unlocked yet! This video showcases all blood clot familiar variants that can be created with the Sumptorium item in The Binding of Isaac Repentance. Rarer clots have unique effects on tearsBone Clot tears have Compound Fracture, Gold Clots have Midas Touch, Eternal Hearts have Sacred Heart, and Black Hearts have Dark Matter. When you take the reverse path back up to Home, the trinket will turn into Cracked Key in the same floor/room you dropped it before. Items picked up are not shared between the two characters, UNLOCK: Unlock this item by defeating The Beast as Tainted Jacob, When activated, Isaac's tears are replaced by a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up for 5 seconds, The sword deals x3 damage if used at close range, or x1.5 damage if charged up and thrown, Clearing rooms doesn't charge this item - charge is added equal to damage taken by enemies. Cain has a 50% chance of firing a shot with the effects of Blood Clot . Seeds yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. Achievements Everything is sold for its shop price, e.g. Teratoma, Envy) then Meat Cleaver will deal a lot of damage and trigger the splitting effect, If the split enemy has low enough health, it will just die instead of splitting, Doesn't work on end-game bosses except Delirium, where it will deal a chunk of damage and spawn a 2nd Delirium to deal with, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Isaac, You no longer take damage from poison/toxic gas/burn effects, and become immune to fear/confusion, This item isn't available in any item pools - you are automatically given it after defeating Dogma, just before The Beast sequence, Grants a one-time use of the Holy Mantle effect, On normal mode this grants The Wafer effect, causing all damage to do a maximum of half a heart each time, Sets your health to 6 hearts if you have fewer than 6. This bug was popularized by a YouTuber called Bisnap and named Brimsnap by a streamer called "CobaltStreak". Items cost 15-30c, trinkets cost 15c, cards/runes cost 6-8c, black/bone hearts 8c, eternal hearts 15c, rotten hearts 5c, UNLOCK: Unlock this item by spending 40+ coins in the same shop, When picked up, this item fully recharges your currently held active item and drops between 2-4 battery pickups. orange, moms wig, Gives a chance to heal 1/2 a red heart every time the in-game timer hits a new minute, There are no restrictions on when the regeneration effect happens as long as the game is not paused, so you can simply afk and heal over time, It's possible to find this item by blowing up Polyps (the weird red rocks found in the Womb floors), * boss room pool, boss room item, the lost item pool, purple, red, lump, When you get hit, you will sometimes cause hearts to drop on the floor, The chance to drop hearts is affected by your luck stat and at +29 Luck it will activate 50% of the time, * boss room pool, boss room item, the lost item pool, plasters, white, Everytime a bomb explodes, it will release a circle of 10 tears outwards, much like the Tammy's Head effect, The tears from each bomb deal a flat 25 damage and are affected by any tear modifiers Isaac has, The tears caused by Sad Bombs are much larger and do a lot more damage than Isaac's normal tears, * boss rush pool, boss rush room, item room, treasure room, item room pool, crying, face, Isaac's tears now bounce off walls and objects in the environment, such as rocks and pots, Allows tears to hit the same enemy multiple times, If you also have Lost Contact, tears will bounce off enemy projectiles instead of being destroyed, UNLOCK: Unlock this item by beating Mom's heart 2 times, * item room, treasure room, item room pool, orange, brown, bottle, jar, As you hold down the fire button, shots will float in the same place until you release the fire key again, Allows you to store up a lot of tears in the air and release them all at once, When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created, * anti gravity, item room, treasure room, item room pool, anti gravity, atom, nucleus, All explosions now heal Isaac for 0.5 red hearts instead of hurting him, REPENTANCE - Pyromaniac now grants Isaac immunity to fire, but no longer protects against stomps or shockwaves. Now grants a half black heart upon use instead of a full soul heart. on enemy death, on room clear, on damage taken etc. Tears down: Delay * 3. His range is unaffected. Bethany : Beat Hard mode as Lazarus without losing a life: Defeat Mom's Heart/It Lives on hard mode as Lazarus, without dying at all: Jacob and Esau If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. Endings. ( : IPECAC Tough Love Technology 2 Mutant Spider Epic Fetus Polyphemus Sacred Heart), Stat Ups: The Sad Onion Max's Head Number One Blood of the Martyr Magic Mushroom Roid Rage Raw Liver Lunch Dinner Dessert Breakfast Rotten Meat Wooden Spoon The Belt Mom's Underwear Mom's Heels Mom's Lipstick Wire Coat Hanger Steven Pentagram The Mark Growth Hormones Mini Mushroom The Pact Small Rock Super Bandage Robo-Baby Little C.H.A.D. A member of the Tulsa-based pop group Hanson said he feels a duty to share his "scary experience" with deep vein thrombosis while health officials in his home state work to promote awareness of the medical condition. Gives Isaac a little portal familiar, that moves across the screen as you're firing, The portal will suck up any consumables and trinkets it travels over, causing it to become larger and deal more contact damage, When the portal sucks up 4 pickups, it turns into a portal that can be used to teleport to unexplored rooms around the floor. After dealing enough damage it will eventually disappear, At full size the flame deals 6x your tear damage, scaling down to 3x at its smallest size, The chance to for each tear to become a flame is affected by your luck stat and at +10 Luck it will activate 50% of the time (starts at 8.33% at +0 Luck), Each tear now has a small chance (3.33%) to be a needle instead, which deals 3 times your tear damage, If a needle hits a non-boss enemy it will instantly kill it and will explode into a circle of 10 more needles, The 10 spawned needles will also deal 3 times your tear damage, but won't instantly kill enemies or explode into more needles, The chance to for each tear to become a needle is affected by your luck stat and at +15 Luck it will activate 50% of the time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lilith, *, black, syringe, injection, euthansia, dang, dan gheesling, dangheesling, dangDEB8, you piece, Upon entering a new room, Isaac will become camouflaged and enemies won't attack until you start firing tears, Camo Undies grants +0.5 speed while cloaked, When uncloaking, all nearby enemies take damage, and Isaac gains a brief tears + damage up, *, pink, purple, goggles underwear under wear, Any time a devil or angel room door opens after a boss, the other one will also spawn, The extra door will only spawn if a devil or angel room was randomly chosen to spawn already, After entering one of the doors, the other will disappear, If there isn't an available wall for the extra door to spawn on, only one door will spawn (i.e. slow, shrink, fear), Spider Mod will also randomly drop battery consumables or blue spiders when a room is completed, For the sake of simplicity for players, all damage values displayed are multiplied by 10 and rounded to the nearest number, This item is a reference to Spider853, creator of Spidermod for the original game and one of the lead developers that worked on Rebirth and its DLCs, *, robot, red, grey, gray, silver, metal, antenna, A familiar that follows Isaac and blocks tears, If a tear hits Farting Baby, there is a 10% chance for it to fart, with 3 possible effects: Charm, Poison or Knock back, Charm deals 5 damage. Deflected tears turn into homing tears and fire back at enemies, dealing 2 damage. Collection Grid white, grey, gray, A familiar that follows isaac around dropping white creep which slows down enemies that walk over it, Spawns 1-2 familiar blue spiders after every room, * item room, treasure room, item room pool, white, ball, dripping, A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight, Robo-Baby 2.0's lasers deal 3.5 damage per hit, UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy), * robo baby 2.0, item room, treasure room, item room pool, red, eyes, grey, gray, robot, A familiar which follows Isaac and spawns a blue flies as you're firing tears, Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, Each use of this item gives +0.7 Damage Up, -0.18 Speed Down and the ability to destroy most obstacles for the current room. These stack with multiple secret rooms - The first one gives +1.00 Tears Up, then all future ones give +0.5. blue, white, triangle, Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral), Despite the increase in tear size, Dead Onion does NOT increase your damage stat. Trinkets Using it with less than 5 coins does nothing, UNLOCK: Unlock this item by collecting 99 coins then spending all of them in the same run, Item Pool: Item Room, Greed Mode Item Room, Upon use, grants use of Brimstone for the current room, If used twice in the same room, the brimstone laser becomes massive and deals +1.8 more damage, Using it more than twice in the same room will give a damage increase each time. Shows you to see the contents of chests, sacks, shopkeepers and items that will drop from fires before you destroy them, Doesn't work on tinted rocks and other obstacles (e.g. Modes After 6 hits, you will stop gaining Damage upgrades. Item Pool: Item Room, Demon Beggar, Lust Miniboss, * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool, red, Item Pool: Item Room, Boss Room, Demon Beggar, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, green, Has a chance to drop from the Gluttony miniboss fight, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull, Can drop from an exploding slot machine while playing it, * slot machine, arcade machine, money, bill, cash, green, * boss rush pool, boss rush room, item room, treasure room, item room pool, grey, gray, x10, UNLOCK: Unlock this item by beating Mom's Heart 3 times, * secret room pool, the lost item pool, brown, noose, hang, Shows most icons on the map (Shops, Item Rooms, Boss Rooms etc. Isaac's tears are replaced with a charged blood laser beam. Amount changed equals the equivalent stat up/down pill. satanic, star, red, black, Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby, Bombs will also synergize with other bomb items and tear modifiers, including Sad Bombs, Mr. Mega and many more, REPENTANCE - Dr. Fetus bombs now scale with the player's tear size and are now immune to knockback from their own explosions. For reference, Rebirth . MEAT! Manage all your favorite fandoms in one place! While you have this flame you also have that item's effect, The flame deals double your tear damage to any enemies that touch it, but if it takes too much damage the flame will disappear and you lose the item's effect, Wisps are randomly chosen from Item Room, Boss Room and Shop item pools, with a 25% chance to pick the same pool as the current room. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. Based on the Steam Workshop mod created by Maddogs, UNLOCK: Unlock this item by picking up Rubber Cement 5 times, Spawns 3 red hearts on the ground when picked up, Added as part of the Afterbirth+ Booster Pack #5, UNLOCK: Unlock this item by defeating Mom's Heart on hard mode as The Forgotten, This item gives you an orbital, which will reflect projectiles back at enemies, Unlike some other orbitals, Slipped Rib doesn't deal contact damage to enemies, UNLOCK: Unlock this item by defeating the Isaac boss as The Forgotten, A familiar which follows Isaac and spawns a white poop when you take damage, The white poop gives an aura that cuts your tear delay in half (Tears up) and has a chance to block damage, The aura disappears if the poop is destroyed. ), Prevents your stats from being reduced any more for the rest of the run, e.g. pill) or picking up the Match Stick trinket, which will burn it off you, *, insect, bug, spider, beetle, grey, gray, brown, While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage, UNLOCK: Unlock this item by beating the Boss Rush with Isaac, At the start of a new floor, you get an eternal heart, UNLOCK: Unlock this item by beating the Dark Room with Maggy, * , the lost item pool, cross, yellow, golden, glow, maggys faith, Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart, UNLOCK: Unlock this item by beating Satan with Judas, * , the lost item pool, tong, red, bloody, lips, judas tongue, Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac, UNLOCK: Unlock this item by beating the Dark Room with Blue Baby, *, dead, baby, blue, ?? 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